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Torbugesic is a veterinary opioid analgesic used to relieve pain, particularly colic in horses, and to manage pain and cough in dogs and cats.

Uses and Indications

Torbugesic (butorphanol tartrate injection) is primarily indicated for relief of pain associated with colic in adult horses and yearlings, including torsion, impaction, intussusception, spasmodic, tympanic colic, and postpartum pain. In dogs and cats, it is used for pain management, sedation, and cough suppression, often in post-operative care or during diagnostic procedures . It is a centrally acting opioid agonist-antagonist, providing analgesia and mild sedation.

Mechanism of Action

Butorphanol is a synthetic opioid that acts as a partial agonist/antagonist at opioid receptors. It provides potent analgesic effects while also exhibiting antitussive activity. In horses, it is 4 to 30 times more potent than morphine, and in humans, it is 5 to 7 times more potent than morphine . Its effects are seen within 15 minutes of injection and typically last about 4 hours .

Dosage and Administration

• Horses: The recommended dose is 0.1 mg/kg intravenously, equivalent to 5 mL per 1000 lbs of body weight. The dose may be repeated every 3–4 hours but should not exceed 48 hours of treatment . Use with caution when combined with other sedatives or analgesics due to additive effects.
• Dogs and Cats: Administered via intravenous, intramuscular, or subcutaneous injection. Dosage is determined by the veterinarian based on species, weight, and condition .

Safety and Precautions

• Do not use in breeding horses, foals, or weanlings due to lack of well-controlled studies .
• Side effects in horses may include slight ataxia (3–10 minutes), mild sedation, dysphoria, or nystagmus .
• In dogs and cats, side effects can include sedation, excitement, respiratory depression, ataxia, anorexia, dilated pupils, or rarely diarrhea. High doses may cause CNS effects such as seizures or cardiovascular changes .
• Use cautiously in animals with liver or kidney impairment, hypothyroidism, heart disease, or CNS dysfunction, and in breeds with MDR1 mutations (e.g., Australian Shepherds, Collies) by reducing dosage 25–50% if necessary
• Not for human use and should not be administered to horses intended for human consumption .

Storage and Handling

• Use contents within 4 months of first puncture .
• As a Schedule IV controlled substance, Torbugesic requires careful handling and prescription by a licensed veterinarian .
  Torbugesic provides a rapid, effective, and short-acting analgesic option for veterinary pain management, particularly in equine colic and small animal pain or cough, with careful attention to dosage, species, and health status.

TORBUGESIC is for the relief of pain associated with colic in adult horses and yearlings. It can be used to alleviate abdominal pain associated with torsion, impaction, intussusception, spasmodic and tympanic colic and postpartum pain.

As part of the trusted equine pain and sedation portfolio from Zoetis, TORBUGESIC is a safe, simple solution for equine abdominal pain relief. Analgesic effects are seen within 15 minutes following injection and persist for approximately four hours.